| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50432933 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_957421 (CHEMBL2378091) |
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| EC50 | 58±n/a nM |
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| Citation |  Nair, SK; Matthews, JJ; Cripps, SJ; Cheng, H; Hoffman, JE; Smith, C; Kupchinsky, S; Siu, M; Taylor, WD; Wang, Y; Johnson, TO; Dress, KR; Edwards, MP; Zhou, S; Hosea, NA; Lapaglia, A; Kang, P; Castro, A; Ermolieff, J; Fanjul, A; Vogel, JE; Rejto, P; Dalvie, D N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11ß-hydroxysteroid dehydrogenase type 1: strategies to eliminate reactive metabolites. Bioorg Med Chem Lett23:2344-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50432933 |
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| n/a |
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| Name | BDBM50432933 |
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| Synonyms: | CHEMBL2377212 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15N3O3S |
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| Mol. Mass. | 365.406 |
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| SMILES | OCc1cccc(NS(=O)(=O)c2ccc(cc2)-c2ccc(cc2)C#N)n1 |
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| Structure | 
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