| Reaction Details |
|---|
 | Report a problem with these data |
| Target | L-lactate dehydrogenase A chain |
|---|
| Ligand | BDBM50433836 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_959391 (CHEMBL2384303) |
|---|
| IC50 | 8800±n/a nM |
|---|
| Citation |  Dragovich, PS; Fauber, BP; Corson, LB; Ding, CZ; Eigenbrot, C; Ge, H; Giannetti, AM; Hunsaker, T; Labadie, S; Liu, Y; Malek, S; Pan, B; Peterson, D; Pitts, K; Purkey, HE; Sideris, S; Ultsch, M; VanderPorten, E; Wei, B; Xu, Q; Yen, I; Yue, Q; Zhang, H; Zhang, X Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett23:3186-94 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| L-lactate dehydrogenase A chain |
|---|
| Name: | L-lactate dehydrogenase A chain |
|---|
| Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36694.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00338::PDB Code: 4ajp |
|---|
| Residue: | 332 |
|---|
| Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
|
|
|
|---|
| BDBM50433836 |
|---|
| n/a |
|---|
| Name | BDBM50433836 |
|---|
| Synonyms: | CHEMBL2382337 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H14ClN5O4S2 |
|---|
| Mol. Mass. | 475.929 |
|---|
| SMILES | NS(=O)(=O)c1ccc(NC(=O)CSc2nc(-c3ccc(Cl)cc3)c(C#N)c(=O)[nH]2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
