Reaction Details |
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Target | Malate dehydrogenase, mitochondrial |
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Ligand | BDBM23229 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_959385 (CHEMBL2384176) |
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IC50 | 8480±n/a nM |
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Citation | Dragovich, PS; Fauber, BP; Corson, LB; Ding, CZ; Eigenbrot, C; Ge, H; Giannetti, AM; Hunsaker, T; Labadie, S; Liu, Y; Malek, S; Pan, B; Peterson, D; Pitts, K; Purkey, HE; Sideris, S; Ultsch, M; VanderPorten, E; Wei, B; Xu, Q; Yen, I; Yue, Q; Zhang, H; Zhang, X Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett23:3186-94 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Malate dehydrogenase, mitochondrial |
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Name: | Malate dehydrogenase, mitochondrial |
Synonyms: | MDH2 | MDHM_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 35512.45 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1456625 |
Residue: | 338 |
Sequence: | MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
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BDBM23229 |
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n/a |
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Name | BDBM23229 |
Synonyms: | Oxamic acid derivative, 7 | [(4-{2-[(5-hydroxy-2-{[(4-methoxyphenyl)methyl]carbamoyl}-4-oxo-4H-chromen-7-yl)oxy]ethyl}-2-methoxyphenyl)carbamoyl]formic acid |
Type | Small organic molecule |
Emp. Form. | C29H26N2O10 |
Mol. Mass. | 562.5241 |
SMILES | COc1ccc(CNC(=O)c2cc(=O)c3c(O)cc(OCCc4ccc(NC(=O)C(O)=O)c(OC)c4)cc3o2)cc1 |
Structure |
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