| Reaction Details |
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 | Report a problem with these data |
| Target | Probable G-protein coupled receptor 142 |
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| Ligand | BDBM50437418 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_972706 (CHEMBL2410915) |
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| EC50 | 1.000000±n/a nM |
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| Citation |  Toda, N; Hao, X; Ogawa, Y; Oda, K; Yu, M; Fu, Z; Chen, Y; Kim, Y; Lizarzaburu, M; Lively, S; Lawlis, S; Murakoshi, M; Nara, F; Watanabe, N; Reagan, JD; Tian, H; Fu, A; Motani, A; Liu, Q; Lin, YJ; Zhuang, R; Xiong, Y; Fan, P; Medina, J; Li, L; Izumi, M; Okuyama, R; Shibuya, S Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes. ACS Med Chem Lett4:790-4 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Probable G-protein coupled receptor 142 |
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| Name: | Probable G-protein coupled receptor 142 |
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| Synonyms: | G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51127.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_985961 |
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| Residue: | 462 |
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| Sequence: | MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQ
VTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATA
GQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVA
LARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFA
ANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMW
RDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILL
GITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKT
FRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
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| BDBM50437418 |
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| n/a |
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| Name | BDBM50437418 |
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| Synonyms: | CHEMBL2409011 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27N7OS |
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| Mol. Mass. | 449.572 |
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| SMILES | CCCCc1c(cnn1-c1ncc(C)c(n1)-c1cccs1)C(=O)NCc1c(C)ncn1C |
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| Structure | 
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