| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50402219 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_979177 (CHEMBL2421977) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Mori, Y; Ogawa, Y; Mochizuki, A; Nakamura, Y; Fujimoto, T; Sugita, C; Miyazaki, S; Tamaki, K; Nagayama, T; Nagai, Y; Inoue, S; Chiba, K; Nishi, T Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors. Bioorg Med Chem21:5907-22 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_MACFA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45012.96 |
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| Organism: | Macaca fascicularis |
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| Description: | ChEMBL_979177 |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLALGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNILSQGVLKEDVFSFYYNRDSENAQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50402219 |
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| n/a |
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| Name | BDBM50402219 |
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| Synonyms: | CHEMBL2204732 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H41ClN4O3 |
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| Mol. Mass. | 493.082 |
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| SMILES | CCOC[C@@H](CC(C)C)NC(=O)[C@@H]1CNC[C@@H](C1)N1CC(=O)N(CC1(C)C)c1ccccc1Cl |r| |
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| Structure | 
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