| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-tyrosine kinase 2-beta |
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| Ligand | BDBM50440370 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_983670 (CHEMBL2427450) |
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| IC50 | 414±n/a nM |
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| Citation |  Grädler, U; Bomke, J; Musil, D; Dresing, V; Lehmann, M; Hölzemann, G; Greiner, H; Esdar, C; Krier, M; Heinrich, T Fragment-based discovery of focal adhesion kinase inhibitors. Bioorg Med Chem Lett23:5401-9 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-tyrosine kinase 2-beta |
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| Name: | Protein-tyrosine kinase 2-beta |
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| Synonyms: | FAK2 | FAK2_HUMAN | PTK2B | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | PYK2 | Protein tyrosine kinase 2 beta | RAFTK |
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| Type: | Protein |
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| Mol. Mass.: | 115868.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14289 |
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| Residue: | 1009 |
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| Sequence: | MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
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| BDBM50440370 |
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| n/a |
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| Name | BDBM50440370 |
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| Synonyms: | CHEMBL2425144 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27N9O |
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| Mol. Mass. | 481.5523 |
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| SMILES | Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(cc1)-n1cnc2c(N)ncnc12)C(C)(C)C |
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| Structure | 
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