Reaction Details |
| Report a problem with these data |
Target | Neurotensin receptor type 1 |
---|
Ligand | BDBM50440737 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_986348 (CHEMBL2433839) |
---|
EC50 | 3410±n/a nM |
---|
Citation | Peddibhotla, S; Hedrick, MP; Hershberger, P; Maloney, PR; Li, Y; Milewski, M; Gosalia, P; Gray, W; Mehta, A; Sugarman, E; Hood, B; Suyama, E; Nguyen, K; Heynen-Genel, S; Vasile, S; Salaniwal, S; Stonich, D; Su, Y; Mangravita-Novo, A; Vicchiarelli, M; Roth, GP; Smith, LH; Chung, TD; Hanson, GR; Thomas, JB; Caron, MG; Barak, LS; Pinkerton, AB Discovery of ML314, a Brain Penetrant Non-Peptidic?-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. ACS Med Chem Lett4:846-851 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neurotensin receptor type 1 |
---|
Name: | Neurotensin receptor type 1 |
Synonyms: | Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1 |
Type: | PROTEIN |
Mol. Mass.: | 46278.89 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1453811 |
Residue: | 418 |
Sequence: | MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM
PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM
SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN
TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH
GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN
PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
|
|
|
BDBM50440737 |
---|
n/a |
---|
Name | BDBM50440737 |
Synonyms: | CHEMBL2431120 |
Type | Small organic molecule |
Emp. Form. | C24H28N4O3 |
Mol. Mass. | 420.5041 |
SMILES | COc1ccccc1N1CCN(CC1)c1nc(nc2cc(OC)c(OC)cc12)C1CC1 |
Structure |
|