Reaction Details |
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Target | Cytochrome P450 2D6 |
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Ligand | BDBM50446303 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1286753 (CHEMBL3111696) |
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IC50 | >10000±n/a nM |
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Citation | Hicken, EJ; Marmsater, FP; Munson, MC; Schlachter, ST; Robinson, JE; Allen, S; Burgess, LE; DeLisle, RK; Rizzi, JP; Topalov, GT; Zhao, Q; Hicks, JM; Kallan, NC; Tarlton, E; Allen, A; Callejo, M; Cox, A; Rana, S; Klopfenstein, N; Woessner, R; Lyssikatos, JP Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability. ACS Med Chem Lett5:78-83 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2D6 |
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Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM50446303 |
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n/a |
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Name | BDBM50446303 |
Synonyms: | CHEMBL3109338 |
Type | Small organic molecule |
Emp. Form. | C24H25FN4O3 |
Mol. Mass. | 436.4787 |
SMILES | COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@H]3CCNC[C@@H]3F)c2n1 |r| |
Structure |
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