Ki Summary

Reaction Details

Report a problem with these data

Target

Oxa40

Ligand

BDBM50447648

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1289443 (CHEMBL3117137)

IC50

>50000±n/a nM

Citation

Blizzard, TA; Chen, H; Kim, S; Wu, J; Bodner, R; Gude, C; Imbriglio, J; Young, K; Park, YW; Ogawa, A; Raghoobar, S; Hairston, N; Painter, RE; Wisniewski, D; Scapin, G; Fitzgerald, P; Sharma, N; Lu, J; Ha, S; Hermes, J; Hammond, ML Discovery of MK-7655, a�-lactamase inhibitor for combination with Primaxin�. Bioorg Med Chem Lett24:780-5 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Oxa40

Name:

Oxa40

Synonyms:

Beta-lactamase | Class D β-lactamase (OXA-24)

Type:

Enzyme

Mol. Mass.:

30946.50

Organism:

Acinetobacter baumannii

Description:

Q8RLA6

Residue:

275

Sequence:

MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEG
KNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMT
LGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEV
NFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQAN
GKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII

BDBM50447648

n/a

Name

BDBM50447648

Synonyms:

CHEMBL3112750

Type

Small organic molecule

Emp. Form.

C13H16N4O6S

Mol. Mass.

356.354

SMILES

Cn1ccc(cc1)=[NH+]C(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS([O-])(=O)=O |r,wD:13.14,10.10,(33.1,-24.04,;34.44,-24.81,;34.43,-26.35,;35.77,-27.12,;37.11,-26.35,;37.1,-24.8,;35.76,-24.04,;38.44,-27.12,;39.77,-26.35,;39.77,-24.81,;41.1,-27.13,;42.44,-26.37,;43.76,-27.16,;43.74,-28.7,;42.4,-29.45,;41.08,-28.66,;41.47,-30.15,;40.38,-31.23,;43.01,-30.15,;43.82,-31.46,;45.36,-31.41,;46.09,-30.06,;45.35,-32.95,;46.89,-31.41,)|

Structure