Reaction Details |
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Target | Protein arginine N-methyltransferase 1 |
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Ligand | BDBM50448487 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1294380 (CHEMBL3129165) |
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IC50 | 300000±n/a nM |
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Citation | Valente, S; Liu, Y; Schnekenburger, M; Zwergel, C; Cosconati, S; Gros, C; Tardugno, M; Labella, D; Florean, C; Minden, S; Hashimoto, H; Chang, Y; Zhang, X; Kirsch, G; Novellino, E; Arimondo, PB; Miele, E; Ferretti, E; Gulino, A; Diederich, M; Cheng, X; Mai, A Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells. J Med Chem57:701-13 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein arginine N-methyltransferase 1 |
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Name: | Protein arginine N-methyltransferase 1 |
Synonyms: | ANM1_RAT | Histone-arginine N-methyltransferase PRMT1 | Hrmt1l2 | Prmt1 |
Type: | PROTEIN |
Mol. Mass.: | 40514.94 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_103589 |
Residue: | 353 |
Sequence: | MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRN
SMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHV
VTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATL
YVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIY
TVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFY
MEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
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BDBM50448487 |
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n/a |
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Name | BDBM50448487 |
Synonyms: | CHEMBL2385821 |
Type | Small organic molecule |
Emp. Form. | C27H23N7O |
Mol. Mass. | 461.5178 |
SMILES | Cc1cc(Nc2cccc(NC(=O)c3ccc(Nc4ccnc5ccccc45)cc3)c2)nc(N)n1 |
Structure |
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