Reaction Details |
| Report a problem with these data |
Target | Coagulation factor X |
---|
Ligand | BDBM50448585 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1296330 (CHEMBL3129589) |
---|
Ki | 641±n/a nM |
---|
Citation | Quan, ML; Wong, PC; Wang, C; Woerner, F; Smallheer, JM; Barbera, FA; Bozarth, JM; Brown, RL; Harpel, MR; Luettgen, JM; Morin, PE; Peterson, T; Ramamurthy, V; Rendina, AR; Rossi, KA; Watson, CA; Wei, A; Zhang, G; Seiffert, D; Wexler, RR Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors. J Med Chem57:955-69 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Coagulation factor X |
---|
Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
BDBM50448585 |
---|
n/a |
---|
Name | BDBM50448585 |
Synonyms: | CHEMBL3127489 |
Type | Small organic molecule |
Emp. Form. | C35H35N5O4 |
Mol. Mass. | 589.6835 |
SMILES | CCCC(=O)Nc1cc(cc(c1)-c1ccc(cc1C(O)=O)C(N)=O)[C@@H]1C[C@](C)(c2ccccc2)c2cc(ccc2N1)C(N)=N |r| |
Structure |
|