| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 |
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| Ligand | BDBM50331809 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1297187 (CHEMBL3131376) |
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| IC50 | 1.000000±n/a nM |
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| Citation |  Siu, T; Kumarasinghe, SE; Altman, MD; Katcher, M; Northrup, A; White, C; Rosenstein, C; Mathur, A; Xu, L; Chan, G; Bachman, E; Bouthillette, M; Dinsmore, CJ; Marshall, CG; Young, JR The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization. Bioorg Med Chem Lett24:1466-71 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 |
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| Name: | Tyrosine-protein kinase JAK2 |
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| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) |
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| Type: | Protein |
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| Mol. Mass.: | 130684.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60674 |
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| Residue: | 1132 |
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| Sequence: | MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
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| BDBM50331809 |
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| n/a |
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| Name | BDBM50331809 |
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| Synonyms: | (R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyrido[4,3-c][1,6]naphthyridin-1(2H)-one | CHEMBL1289218 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15F3N4O |
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| Mol. Mass. | 336.3117 |
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| SMILES | CC(C)[C@@H](Nc1nc2cc[nH]c(=O)c2c2cnccc12)C(F)(F)F |r| |
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| Structure | 
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