Compile Data Set for Download or QSAR

Found 285 hits with Last Name = 'katcher' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449372 (CHEMBL3126350) Show SMILES NS(=O)(=O)c1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C17H11Cl2N5O3S/c18-11-5-8(28(20,26)27)6-12(19)15(11)24-16-9-1-4-22-17(25)14(9)10-7-21-3-2-13(10)23-16/h1-7H,(H,22,25)(H,23,24)(H2,20,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449373 (CHEMBL3126349) Show SMILES OC(C(F)F)c1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C19H12Cl2F2N4O2/c20-11-5-8(16(28)17(22)23)6-12(21)15(11)27-18-9-1-4-25-19(29)14(9)10-7-24-3-2-13(10)26-18/h1-7,16-17,28H,(H,25,29)(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449375 (CHEMBL3126347) Show SMILES CC(C)(O)c1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C20H16Cl2N4O2/c1-20(2,28)10-7-13(21)17(14(22)8-10)26-18-11-3-6-24-19(27)16(11)12-9-23-5-4-15(12)25-18/h3-9,28H,1-2H3,(H,24,27)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449376 (CHEMBL3126346) Show SMILES CC(O)c1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C19H14Cl2N4O2/c1-9(26)10-6-13(20)17(14(21)7-10)25-18-11-2-5-23-19(27)16(11)12-8-22-4-3-15(12)24-18/h2-9,26H,1H3,(H,23,27)(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449381 (CHEMBL3126341) Show SMILES Fc1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C17H9Cl2FN4O/c18-11-5-8(20)6-12(19)15(11)24-16-9-1-4-22-17(25)14(9)10-7-21-3-2-13(10)23-16/h1-7H,(H,22,25)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449383 (CHEMBL3126352) Show SMILES Fc1cc(F)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C17H9ClF2N4O/c18-11-5-8(19)6-12(20)15(11)24-16-9-1-4-22-17(25)14(9)10-7-21-3-2-13(10)23-16/h1-7H,(H,22,25)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449374 (CHEMBL3126348) Show SMILES Clc1cc(cc(Cl)c1Nc1nc2ccncc2c2c1cc[nH]c2=O)-c1cc[nH]n1 Show InChI InChI=1S/C20H12Cl2N6O/c21-13-7-10(15-3-6-25-28-15)8-14(22)18(13)27-19-11-1-5-24-20(29)17(11)12-9-23-4-2-16(12)26-19/h1-9H,(H,24,29)(H,25,28)(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 | MK-8033) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccccn4)cc3c(=O)c2c1 Show InChI InChI=1S/C25H21N5O3S/c1-30-15-20(13-28-30)19-11-23-24(27-12-19)8-7-18-6-5-17(10-22(18)25(23)31)16-34(32,33)29-14-21-4-2-3-9-26-21/h2-13,15,29H,14,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427143 (CHEMBL2323783) Show SMILES O=c1c2cc(CS(=O)(=O)NCc3ccccn3)ccc2ccc2ncc(cc12)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C29H28N6O3S/c36-29-26-13-20(19-39(37,38)34-17-24-3-1-2-10-31-24)4-5-21(26)6-7-28-27(29)14-22(15-32-28)23-16-33-35(18-23)25-8-11-30-12-9-25/h1-7,10,13-16,18,25,30,34H,8-9,11-12,17,19H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50331809 ((R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyr...) Show SMILES CC(C)[C@@H](Nc1nc2cc[nH]c(=O)c2c2cnccc12)C(F)(F)F |r| Show InChI InChI=1S/C16H15F3N4O/c1-8(2)13(16(17,18)19)23-14-9-3-5-20-7-10(9)12-11(22-14)4-6-21-15(12)24/h3-8,13H,1-2H3,(H,21,24)(H,22,23)/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427155 (CHEMBL2323770) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4cccnn4)cc3c(=O)c2c1 Show InChI InChI=1S/C24H20N6O3S/c1-30-14-19(12-27-30)18-10-22-23(25-11-18)7-6-17-5-4-16(9-21(17)24(22)31)15-34(32,33)28-13-20-3-2-8-26-29-20/h2-12,14,28H,13,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449378 (CHEMBL3126344) Show SMILES FC(F)(F)c1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C18H9Cl2F3N4O/c19-11-5-8(18(21,22)23)6-12(20)15(11)27-16-9-1-4-25-17(28)14(9)10-7-24-3-2-13(10)26-16/h1-7H,(H,25,28)(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427172 (CHEMBL2323777) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4cccc[n+]4[O-])cc3c(=O)c2c1 Show InChI InChI=1S/C25H21N5O4S/c1-29-15-20(13-27-29)19-11-23-24(26-12-19)8-7-18-6-5-17(10-22(18)25(23)31)16-35(33,34)28-14-21-4-2-3-9-30(21)32/h2-13,15,28H,14,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50347659 (CHEMBL1802916 | MK-2461) Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r| Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449380 (CHEMBL3126342) Show SMILES Clc1cncc(Cl)c1Nc1nc2ccncc2c2c1cc[nH]c2=O Show InChI InChI=1S/C16H9Cl2N5O/c17-10-6-20-7-11(18)14(10)23-15-8-1-4-21-16(24)13(8)9-5-19-3-2-12(9)22-15/h1-7H,(H,21,24)(H,20,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427154 (CHEMBL2323771) Show SMILES Cc1nccc(CNS(=O)(=O)Cc2ccc3ccc4ncc(cc4c(=O)c3c2)-c2cnn(C)c2)n1 Show InChI InChI=1S/C25H22N6O3S/c1-16-26-8-7-21(30-16)13-29-35(33,34)15-17-3-4-18-5-6-24-23(25(32)22(18)9-17)10-19(11-27-24)20-12-28-31(2)14-20/h3-12,14,29H,13,15H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50347658 (CHEMBL1802917) Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(c1)C1CCNCC1 |r| Show InChI InChI=1S/C28H32N6O5S/c1-33(17-24-18-38-10-11-39-24)40(36,37)32-22-4-2-19-3-5-27-26(28(35)25(19)13-22)12-20(14-30-27)21-15-31-34(16-21)23-6-8-29-9-7-23/h2-5,12-16,23-24,29,32H,6-11,17-18H2,1H3/t24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449379 (CHEMBL3126343) Show SMILES FC(F)(F)Oc1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C18H9Cl2F3N4O2/c19-11-5-8(29-18(21,22)23)6-12(20)15(11)27-16-9-1-4-25-17(28)14(9)10-7-24-3-2-13(10)26-16/h1-7H,(H,25,28)(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427153 (CHEMBL2323772) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4cnsc4)cc3c(=O)c2c1 Show InChI InChI=1S/C23H19N5O3S2/c1-28-12-19(11-25-28)18-7-21-22(24-10-18)5-4-17-3-2-15(6-20(17)23(21)29)14-33(30,31)27-9-16-8-26-32-13-16/h2-8,10-13,27H,9,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427151 (CHEMBL2323774) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccncc4)cc3c(=O)c2c1 Show InChI InChI=1S/C25H21N5O3S/c1-30-15-21(14-28-30)20-11-23-24(27-13-20)5-4-19-3-2-18(10-22(19)25(23)31)16-34(32,33)29-12-17-6-8-26-9-7-17/h2-11,13-15,29H,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50347681 (CHEMBL1802829) Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 Show InChI InChI=1S/C20H19N5O3S/c1-24(2)29(27,28)23-16-6-4-13-5-7-19-18(20(26)17(13)9-16)8-14(10-21-19)15-11-22-25(3)12-15/h4-12,23H,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427156 (CHEMBL2323769) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccccc4Cl)cc3c(=O)c2c1 Show InChI InChI=1S/C26H21ClN4O3S/c1-31-15-21(13-29-31)20-11-23-25(28-12-20)9-8-18-7-6-17(10-22(18)26(23)32)16-35(33,34)30-14-19-4-2-3-5-24(19)27/h2-13,15,30H,14,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427157 (CHEMBL2324128) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccc(F)cc4F)cc3c(=O)c2c1 Show InChI InChI=1S/C26H20F2N4O3S/c1-32-14-20(12-30-32)19-9-23-25(29-11-19)7-5-17-3-2-16(8-22(17)26(23)33)15-36(34,35)31-13-18-4-6-21(27)10-24(18)28/h2-12,14,31H,13,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 | MK-8033) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccccn4)cc3c(=O)c2c1 Show InChI InChI=1S/C25H21N5O3S/c1-30-15-20(13-28-30)19-11-23-24(27-12-19)8-7-18-6-5-17(10-22(18)25(23)31)16-34(32,33)29-14-21-4-2-3-9-26-21/h2-13,15,29H,14,16H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of RON (unknown origin) by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449382 (CHEMBL3126340) Show SMILES Fc1cc(F)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(F)c1 Show InChI InChI=1S/C17H9F3N4O/c18-8-5-11(19)15(12(20)6-8)24-16-9-1-4-22-17(25)14(9)10-7-21-3-2-13(10)23-16/h1-7H,(H,22,25)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50347681 (CHEMBL1802829) Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 Show InChI InChI=1S/C20H19N5O3S/c1-24(2)29(27,28)23-16-6-4-13-5-7-19-18(20(26)17(13)9-16)8-14(10-21-19)15-11-22-25(3)12-15/h4-12,23H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of RON (unknown origin) by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427144 (CHEMBL2323782) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NC4CCCCC4)cc3c(=O)c2c1 Show InChI InChI=1S/C25H26N4O3S/c1-29-15-20(14-27-29)19-12-23-24(26-13-19)10-9-18-8-7-17(11-22(18)25(23)30)16-33(31,32)28-21-5-3-2-4-6-21/h7-15,21,28H,2-6,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427152 (CHEMBL2323773) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4cccnc4)cc3c(=O)c2c1 Show InChI InChI=1S/C25H21N5O3S/c1-30-15-21(14-28-30)20-10-23-24(27-13-20)7-6-19-5-4-17(9-22(19)25(23)31)16-34(32,33)29-12-18-3-2-8-26-11-18/h2-11,13-15,29H,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449377 (CHEMBL3126345) Show SMILES Fc1cccc(c1Nc1nc2ccncc2c2c1cc[nH]c2=O)C(F)(F)F Show InChI InChI=1S/C18H10F4N4O/c19-12-3-1-2-11(18(20,21)22)15(12)26-16-9-4-7-24-17(27)14(9)10-8-23-6-5-13(10)25-16/h1-8H,(H,24,27)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427145 (CHEMBL2323781) Show SMILES CN(c1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1)S(=O)(=O)NCc1ccccn1 Show InChI InChI=1S/C25H22N6O3S/c1-30-16-19(14-28-30)18-11-23-24(27-13-18)9-7-17-6-8-21(12-22(17)25(23)32)31(2)35(33,34)29-15-20-5-3-4-10-26-20/h3-14,16,29H,15H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449384 (CHEMBL3126351) Show SMILES CC(C)[C@H](Nc1nc2ccncc2c2c1cc[nH]c2=O)C(F)(F)F |r| Show InChI InChI=1S/C16H15F3N4O/c1-8(2)13(16(17,18)19)23-14-9-3-6-21-15(24)12(9)10-7-20-5-4-11(10)22-14/h3-8,13H,1-2H3,(H,21,24)(H,22,23)/t13-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427159 (CHEMBL2324126) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccccc4)cc3c(=O)c2c1 Show InChI InChI=1S/C26H22N4O3S/c1-30-16-22(15-28-30)21-12-24-25(27-14-21)10-9-20-8-7-19(11-23(20)26(24)31)17-34(32,33)29-13-18-5-3-2-4-6-18/h2-12,14-16,29H,13,17H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449376 (CHEMBL3126346) Show SMILES CC(O)c1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C19H14Cl2N4O2/c1-9(26)10-6-13(20)17(14(21)7-10)25-18-11-2-5-23-19(27)16(11)12-8-22-4-3-15(12)24-18/h2-9,26H,1H3,(H,23,27)(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449381 (CHEMBL3126341) Show SMILES Fc1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C17H9Cl2FN4O/c18-11-5-8(20)6-12(19)15(11)24-16-9-1-4-22-17(25)14(9)10-7-21-3-2-13(10)23-16/h1-7H,(H,22,25)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427161 (CHEMBL2324124) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)N[C@@H]4CCCC[C@H]4N)cc3c(=O)c2c1 |r| Show InChI InChI=1S/C25H27N5O3S/c1-30-14-19(13-28-30)18-11-21-23(27-12-18)9-8-17-7-6-16(10-20(17)25(21)31)15-34(32,33)29-24-5-3-2-4-22(24)26/h6-14,22,24,29H,2-5,15,26H2,1H3/t22-,24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449383 (CHEMBL3126352) Show SMILES Fc1cc(F)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C17H9ClF2N4O/c18-11-5-8(19)6-12(20)15(11)24-16-9-1-4-22-17(25)14(9)10-7-21-3-2-13(10)23-16/h1-7H,(H,22,25)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449375 (CHEMBL3126347) Show SMILES CC(C)(O)c1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C20H16Cl2N4O2/c1-20(2,28)10-7-13(21)17(14(22)8-10)26-18-11-3-6-24-19(27)16(11)12-9-23-5-4-15(12)25-18/h3-9,28H,1-2H3,(H,24,27)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449380 (CHEMBL3126342) Show SMILES Clc1cncc(Cl)c1Nc1nc2ccncc2c2c1cc[nH]c2=O Show InChI InChI=1S/C16H9Cl2N5O/c17-10-6-20-7-11(18)14(10)23-15-8-1-4-21-16(24)13(8)9-5-19-3-2-12(9)22-15/h1-7H,(H,21,24)(H,20,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449373 (CHEMBL3126349) Show SMILES OC(C(F)F)c1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C19H12Cl2F2N4O2/c20-11-5-8(16(28)17(22)23)6-12(21)15(11)27-18-9-1-4-25-19(29)14(9)10-7-24-3-2-13(10)26-18/h1-7,16-17,28H,(H,25,29)(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 | MK-8033) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccccn4)cc3c(=O)c2c1 Show InChI InChI=1S/C25H21N5O3S/c1-30-15-20(13-28-30)19-11-23-24(27-12-19)8-7-18-6-5-17(10-22(18)25(23)31)16-34(32,33)29-14-21-4-2-3-9-26-21/h2-13,15,29H,14,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of HGF-stimulated c-MET (unknown origin) autophosphorylation at tyrosine 1349 expressed in human GTL16 cells after 2 hrs by Western blotti...				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427139 (CHEMBL2324117) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(cc3c(=O)c2c1)C(O)C(N)=O Show InChI InChI=1S/C20H16N4O3/c1-24-10-14(9-23-24)13-7-16-17(22-8-13)5-4-11-2-3-12(18(25)20(21)27)6-15(11)19(16)26/h2-10,18,25H,1H3,(H2,21,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427160 (CHEMBL2324125) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)Nc4ccccc4)cc3c(=O)c2c1 Show InChI InChI=1S/C25H20N4O3S/c1-29-15-20(14-27-29)19-12-23-24(26-13-19)10-9-18-8-7-17(11-22(18)25(23)30)16-33(31,32)28-21-5-3-2-4-6-21/h2-15,28H,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449374 (CHEMBL3126348) Show SMILES Clc1cc(cc(Cl)c1Nc1nc2ccncc2c2c1cc[nH]c2=O)-c1cc[nH]n1 Show InChI InChI=1S/C20H12Cl2N6O/c21-13-7-10(15-3-6-25-28-15)8-14(22)18(13)27-19-11-1-5-24-20(29)17(11)12-9-23-4-2-16(12)26-19/h1-9H,(H,24,29)(H,25,28)(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50331809 ((R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyr...) Show SMILES CC(C)[C@@H](Nc1nc2cc[nH]c(=O)c2c2cnccc12)C(F)(F)F |r| Show InChI InChI=1S/C16H15F3N4O/c1-8(2)13(16(17,18)19)23-14-9-3-5-20-7-10(9)12-11(22-14)4-6-21-15(12)24/h3-8,13H,1-2H3,(H,21,24)(H,22,23)/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427164 (CHEMBL2324121) Show SMILES CCCNS(=O)(=O)Cc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 Show InChI InChI=1S/C22H22N4O3S/c1-3-8-25-30(28,29)14-15-4-5-16-6-7-21-20(22(27)19(16)9-15)10-17(11-23-21)18-12-24-26(2)13-18/h4-7,9-13,25H,3,8,14H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427163 (CHEMBL2324122) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCC4COCCO4)cc3c(=O)c2c1 Show InChI InChI=1S/C24H24N4O5S/c1-28-13-19(11-26-28)18-9-22-23(25-10-18)5-4-17-3-2-16(8-21(17)24(22)29)15-34(30,31)27-12-20-14-32-6-7-33-20/h2-5,8-11,13,20,27H,6-7,12,14-15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449378 (CHEMBL3126344) Show SMILES FC(F)(F)c1cc(Cl)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C18H9Cl2F3N4O/c19-11-5-8(18(21,22)23)6-12(20)15(11)27-16-9-1-4-25-17(28)14(9)10-7-24-3-2-13(10)26-16/h1-7H,(H,25,28)(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427158 (CHEMBL2324127) Show SMILES CC(NS(=O)(=O)Cc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1)c1ccccc1 Show InChI InChI=1S/C27H24N4O3S/c1-18(20-6-4-3-5-7-20)30-35(33,34)17-19-8-9-21-10-11-26-25(27(32)24(21)12-19)13-22(14-28-26)23-15-29-31(2)16-23/h3-16,18,30H,17H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427162 (CHEMBL2324123) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)N[C@@H]4CCCC[C@@H]4N)cc3c(=O)c2c1 |r| Show InChI InChI=1S/C25H27N5O3S/c1-30-14-19(13-28-30)18-11-21-23(27-12-18)9-8-17-7-6-16(10-20(17)25(21)31)15-34(32,33)29-24-5-3-2-4-22(24)26/h6-14,22,24,29H,2-5,15,26H2,1H3/t22-,24+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427170 (CHEMBL2323779) Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCCc4ccccn4)cc3c(=O)c2c1 Show InChI InChI=1S/C26H23N5O3S/c1-31-16-21(15-29-31)20-13-24-25(28-14-20)8-7-19-6-5-18(12-23(19)26(24)32)17-35(33,34)30-11-9-22-4-2-3-10-27-22/h2-8,10,12-16,30H,9,11,17H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
					More data for this Ligand-Target Pair

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