Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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Ligand | BDBM50018808 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1362858 (CHEMBL3295808) |
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IC50 | 138±n/a nM |
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Citation | Gillespie, P; Pietranico-Cole, S; Myers, M; Bilotta, JA; Conde-Knape, K; Fotouhi, N; Goodnow, RA; Guertin, KR; Hamilton, MM; Haynes, NE; Liu, B; Qi, L; Ren, Y; Scott, NR; So, SS; Spence, C; Taub, R; Thakkar, K; Tilley, JW; Zwingelstein, C Discovery of camphor-derived pyrazolones as 11ß-hydroxysteroid dehydrogenase type 1 inhibitors. Bioorg Med Chem Lett24:2707-11 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase 1 |
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Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1 |
Type: | Enzyme |
Mol. Mass.: | 31889.48 |
Organism: | Rattus norvegicus (rat) |
Description: | P16232 |
Residue: | 288 |
Sequence: | MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLT
ARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQT
TMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYS
ASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALE
IIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
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BDBM50018808 |
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n/a |
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Name | BDBM50018808 |
Synonyms: | CHEMBL3291337 |
Type | Small organic molecule |
Emp. Form. | C18H22N2O |
Mol. Mass. | 282.3801 |
SMILES | [H][C@@]12CC[C@@](C)(c3c1c(=O)n(-c1ccccc1)n3C)C2(C)C |r| |
Structure |
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