| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member C4 |
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| Ligand | BDBM50024764 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1438120 (CHEMBL3388495) |
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| IC50 | 20000±n/a nM |
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| Citation |  Endo, S; Hu, D; Matsunaga, T; Otsuji, Y; El-Kabbani, O; Kandeel, M; Ikari, A; Hara, A; Kitade, Y; Toyooka, N Synthesis of non-prenyl analogues of baccharin as selective and potent inhibitors for aldo-keto reductase 1C3. Bioorg Med Chem22:5220-33 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member C4 |
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| Name: | Aldo-keto reductase family 1 member C4 |
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| Synonyms: | 3-alpha-HSD1 | 3-alpha-Hydroxysteroid Dehydrogenase Type 1 (AKR1C4) | 3-alpha-hydroxysteroid dehydrogenase type I | AK1C4_HUMAN | AKR1C4 | Aldo-keto reductase family 1 member C4 | Aldo-keto reductase family 1 member C4 (AK1C4) | CDR | CHDR | Chlordecone reductase | DD-4 | DD4 | Dihydrodiol dehydrogenase 4 | HAKRA |
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| Type: | Enzyme |
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| Mol. Mass.: | 37068.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P17516 |
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| Residue: | 323 |
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| Sequence: | MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
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| BDBM50024764 |
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| n/a |
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| Name | BDBM50024764 |
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| Synonyms: | CHEMBL3337721 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22O6 |
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| Mol. Mass. | 418.4386 |
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| SMILES | OC(=O)\C=C\c1ccc(OC(=O)CCc2ccccc2)c(OCc2cccc(O)c2)c1 |
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| Structure | 
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