Reaction Details |
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Target | Isocitrate dehydrogenase [NADP] cytoplasmic |
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Ligand | BDBM50029488 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1436947 (CHEMBL3389006) |
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Ki | 800±n/a nM |
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Citation | Liu, Z; Yao, Y; Kogiso, M; Zheng, B; Deng, L; Qiu, JJ; Dong, S; Lv, H; Gallo, JM; Li, XN; Song, Y Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. J Med Chem57:8307-18 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Isocitrate dehydrogenase [NADP] cytoplasmic |
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Name: | Isocitrate dehydrogenase [NADP] cytoplasmic |
Synonyms: | Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD |
Type: | Protein |
Mol. Mass.: | 46661.29 |
Organism: | Homo sapiens (Human) |
Description: | O75874 |
Residue: | 414 |
Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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BDBM50029488 |
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n/a |
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Name | BDBM50029488 |
Synonyms: | CHEMBL3343462 |
Type | Small organic molecule |
Emp. Form. | C20H19NO3 |
Mol. Mass. | 321.3698 |
SMILES | COc1ccc(cc1)-c1ccc(Cc2cc(C)cc(=O)n2O)cc1 |
Structure |
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