Reaction Details | |||
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Target | Coagulation factor X | ||
Ligand | BDBM50032862 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1443465 (CHEMBL3377179) | ||
Ki | >8180±n/a nM | ||
Citation | Hangeland, JJ; Friends, TJ; Rossi, KA; Smallheer, JM; Wang, C; Sun, Z; Corte, JR; Fang, T; Wong, PC; Rendina, AR; Barbera, FA; Bozarth, JM; Luettgen, JM; Watson, CA; Zhang, G; Wei, A; Ramamurthy, V; Morin, PE; Bisacchi, GS; Subramaniam, S; Arunachalam, P; Mathur, A; Seiffert, DA; Wexler, RR; Quan, ML Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity. J Med Chem57:9915-32 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Coagulation factor X | |||
Name: | Coagulation factor X | ||
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor | ||
Type: | Enzyme | ||
Mol. Mass.: | 54726.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 488 | ||
Sequence: |
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BDBM50032862 | |||
n/a | |||
Name | BDBM50032862 | ||
Synonyms: | CHEMBL3355668 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H30F3N5O3 | ||
Mol. Mass. | 541.5647 | ||
SMILES | OC(=O)C(F)(F)F.NC[C@H]1CC[C@@H](CC1)C(=O)N[C@@H](Cc1ccccc1)c1nc(c[nH]1)-c1cccc(c1)C#N |r,wU:18.18,12.14,wD:9.7,(24.99,-5.26,;26.33,-6.03,;26.33,-7.58,;27.66,-5.26,;28.99,-6.03,;28.99,-4.47,;27.66,-3.72,;9.31,-12.83,;10.63,-13.61,;11.97,-12.84,;13.31,-13.62,;14.65,-12.85,;14.64,-11.31,;13.32,-10.54,;11.98,-11.3,;15.98,-10.54,;15.98,-9,;17.31,-11.31,;18.65,-10.54,;18.65,-9,;19.98,-8.23,;21.31,-9,;22.65,-8.23,;22.65,-6.69,;21.31,-5.92,;19.98,-6.69,;19.98,-11.31,;21.38,-10.68,;22.41,-11.82,;21.64,-13.16,;20.14,-12.84,;23.94,-11.67,;24.56,-10.26,;26.09,-10.1,;27,-11.34,;26.37,-12.75,;24.84,-12.91,;27.28,-13.99,;28.19,-15.23,)| | ||
Structure |