| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
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| Ligand | BDBM50034642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1440217 (CHEMBL3383762) |
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| IC50 | 2300±n/a nM |
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| Citation |  Shao, YX; Huang, M; Cui, W; Feng, LJ; Wu, Y; Cai, Y; Li, Z; Zhu, X; Liu, P; Wan, Y; Ke, H; Luo, HB Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent. J Med Chem57:10304-13 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
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| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
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| Synonyms: | 63 kDa Cam-PDE | Calcium/calmodulin-dependent 3 ,5 -cyclic nucleotide phosphodiesterase 1B | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Cam-PDE 1B | PDE1B | PDE1B1 | PDE1B_HUMAN | PDES1B | Phosphodiesterase 1B | Phosphodiesterase 1B (PDE1B1) | Phosphodiesterase Type 1 (PDE1B) | Phosphodiesterase, PDE1/PDE5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 61366.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 536 |
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| Sequence: | MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL
EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP
KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL
RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL
RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV
FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK
ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS
QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS
FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
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| BDBM50034642 |
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| n/a |
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| Name | BDBM50034642 |
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| Synonyms: | CHEMBL3360416 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N6O3 |
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| Mol. Mass. | 396.443 |
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| SMILES | COc1ccc(NC(=O)[C@H](C)Nc2nc3n(ncc3c(=O)[nH]2)C2CCCC2)cc1 |r| |
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| Structure | 
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