| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
|---|
| Ligand | BDBM50043408 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1444991 (CHEMBL3372399) |
|---|
| IC50 | 84±n/a nM |
|---|
| Citation |  Barsanti, PA; Pan, Y; Lu, Y; Jain, R; Cox, M; Aversa, RJ; Dillon, MP; Elling, R; Hu, C; Jin, X; Knapp, M; Lan, J; Ramurthy, S; Rudewicz, P; Setti, L; Subramanian, S; Mathur, M; Taricani, L; Thomas, G; Xiao, L; Yue, Q Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors. ACS Med Chem Lett6:42-6 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Chk1 |
|---|
| Name: | Serine/threonine-protein kinase Chk1 |
|---|
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 54443.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_166295192 |
|---|
| Residue: | 476 |
|---|
| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
|
|
|
|---|
| BDBM50043408 |
|---|
| n/a |
|---|
| Name | BDBM50043408 |
|---|
| Synonyms: | CHEMBL3355475 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H20N6O |
|---|
| Mol. Mass. | 348.4017 |
|---|
| SMILES | C[C@@H]1COCCN1c1nc(cc2n(C)cnc12)-c1cncc2[nH]ccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
