Reaction Details |
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Target | Nicotinamide phosphoribosyltransferase |
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Ligand | BDBM50060765 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1462152 (CHEMBL3396926) |
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IC50 | 84±n/a nM |
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Citation | Zak, M; Liederer, BM; Sampath, D; Yuen, PW; Bair, KW; Baumeister, T; Buckmelter, AJ; Clodfelter, KH; Cheng, E; Crocker, L; Fu, B; Han, B; Li, G; Ho, YC; Lin, J; Liu, X; Ly, J; O'Brien, T; Reynolds, DJ; Skelton, N; Smith, CC; Tay, S; Wang, W; Wang, Z; Xiao, Y; Zhang, L; Zhao, G; Zheng, X; Dragovich, PS Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. Bioorg Med Chem Lett25:529-41 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nicotinamide phosphoribosyltransferase |
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Name: | Nicotinamide phosphoribosyltransferase |
Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
Type: | Enzyme |
Mol. Mass.: | 55524.98 |
Organism: | Homo sapiens (Human) |
Description: | P43490 |
Residue: | 491 |
Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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BDBM50060765 |
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n/a |
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Name | BDBM50060765 |
Synonyms: | CHEMBL3394739 | US9458172, 175 |
Type | Small organic molecule |
Emp. Form. | C20H20N6O3S |
Mol. Mass. | 424.476 |
SMILES | CC(C)n1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3cnccc3[nH]2)nc1 |
Structure |
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