Reaction Details |
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Target | Sphingosine 1-phosphate receptor 1 |
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Ligand | BDBM50063892 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1463789 (CHEMBL3404799) |
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EC50 | 1.7±n/a nM |
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Citation | Buzard, DJ; Schrader, TO; Zhu, X; Lehmann, J; Johnson, B; Kasem, M; Kim, SH; Kawasaki, A; Lopez, L; Moody, J; Han, S; Gao, Y; Edwards, J; Barden, J; Thatte, J; Gatlin, J; Jones, RM Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor. Bioorg Med Chem Lett25:659-63 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine 1-phosphate receptor 1 |
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Name: | Sphingosine 1-phosphate receptor 1 |
Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
Type: | Enzyme |
Mol. Mass.: | 42836.02 |
Organism: | Homo sapiens (Human) |
Description: | P21453 |
Residue: | 382 |
Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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BDBM50063892 |
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n/a |
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Name | BDBM50063892 |
Synonyms: | CHEMBL3403628 |
Type | Small organic molecule |
Emp. Form. | C24H24N2O5 |
Mol. Mass. | 420.4578 |
SMILES | CC(C)Oc1ccc(COc2ccc3n4CCOC(CC(O)=O)c4cc3c2)cc1C#N |
Structure |
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