| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50063864 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1463795 (CHEMBL3404805) |
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| EC50 | 0.040000±n/a nM |
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| Citation |  Buzard, DJ; Schrader, TO; Zhu, X; Lehmann, J; Johnson, B; Kasem, M; Kim, SH; Kawasaki, A; Lopez, L; Moody, J; Han, S; Gao, Y; Edwards, J; Barden, J; Thatte, J; Gatlin, J; Jones, RM Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor. Bioorg Med Chem Lett25:659-63 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | S1PR1 | Sphingosine-1-phosphate receptor 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42410.96 |
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| Organism: | Canis lupus familiaris |
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| Description: | ChEMBL_109735 |
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| Residue: | 381 |
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| Sequence: | MGSTSVPLVKALRSPVSDYVNYDIIVRHYNYTGKLNTSADKENGIKMSSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDPLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLVLGGLPIM
GWNCIGALASCPTVLPLYHKHYILFCTTVFTLLLLAIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPPFILLLDVGCKVKTCDILFRAEYFLVLAV
LNSGTNPIIYTLTNKEMRRAFIRILSCCKCPGGDPAGKFKRPIIAGVEFSRSKSDNSSHP
QKDDGDNPETVMSSGNVNSSS
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| BDBM50063864 |
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| n/a |
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| Name | BDBM50063864 |
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| Synonyms: | CHEMBL3403619 | US10676467, Compound TZ 50 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27F3N2O3 |
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| Mol. Mass. | 472.4994 |
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| SMILES | OC(=O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(c3)C(F)(F)F)cc21 |
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| Structure | 
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