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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M1 | ||
| Ligand | BDBM50066860 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1465996 (CHEMBL3406978) | ||
| IC50 | 1.000000±n/a nM | ||
| Citation |  Prat, M; Buil, MA; Fernández, MD; Tort, L; Monleón, JM; Casals, G; Ferrer, M; Castro, J; Gavaldà, A; Miralpeix, M; Ramos, I; Vilella, D; Huerta, JM; Espinosa, S; Hernández, B; Segarra, V; Córdoba, M Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists. Bioorg Med Chem Lett25:1736-41 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M1 | |||
| Name: | Muscarinic acetylcholine receptor M1 | ||
| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51442.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11229 | ||
| Residue: | 460 | ||
| Sequence: |
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| BDBM50066860 | |||
| n/a | |||
| Name | BDBM50066860 | ||
| Synonyms: | CHEMBL3401648 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H31BrN2O2S2 | ||
| Mol. Mass. | 547.571 | ||
| SMILES | [Br-].OC(C(=O)N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1 |r,wD:6.4,(12.05,-2.25,;-.84,-3.54,;.32,-3.97,;1.5,-2.98,;2.66,-3.41,;1.24,-1.46,;2.43,-.47,;3.99,-1.04,;5.25,.01,;6.45,-.91,;6.25,-2.44,;7.48,-3.38,;7.28,-4.9,;8.5,-5.84,;8.3,-7.37,;6.88,-7.96,;5.66,-7.02,;5.86,-5.49,;4.96,1.62,;3.4,2.19,;2.17,1.13,;3.39,1.58,;4.58,1.15,;.58,-5.49,;1.95,-6.15,;1.73,-7.67,;.21,-7.93,;-.5,-6.57,;.06,-2.45,;-1.46,-2.3,;-1.78,-.79,;-.44,-.03,;.7,-1.07,)| | ||
| Structure | 
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