Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M1 | ||
| Ligand | BDBM50066866 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1465996 (CHEMBL3406978) | ||
| IC50 | 0.400000±n/a nM | ||
| Citation |  Prat, M; Buil, MA; Fernández, MD; Tort, L; Monleón, JM; Casals, G; Ferrer, M; Castro, J; Gavaldà, A; Miralpeix, M; Ramos, I; Vilella, D; Huerta, JM; Espinosa, S; Hernández, B; Segarra, V; Córdoba, M Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists. Bioorg Med Chem Lett25:1736-41 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M1 | |||
| Name: | Muscarinic acetylcholine receptor M1 | ||
| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51442.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11229 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM50066866 | |||
| n/a | |||
| Name | BDBM50066866 | ||
| Synonyms: | CHEMBL3401643 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H26N2O2S | ||
| Mol. Mass. | 334.476 | ||
| SMILES | O[C@@](C1CCCC1)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1 |r,wD:10.10,1.20,(-1.96,.59,;-.74,.79,;.78,1.05,;1.85,-.04,;3.22,.67,;2.97,2.19,;1.44,2.42,;.24,-.4,;1.25,-.23,;-.3,-1.84,;.68,-3.03,;.11,-4.54,;1.15,-5.77,;2.75,-5.49,;3.3,-3.95,;2.27,-2.71,;1.35,-3.62,;2.14,-4.59,;-.2,2.24,;1.05,3.11,;.59,4.58,;-.95,4.59,;-1.44,3.13,)| | ||
| Structure | 
| ||