| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50071092 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1468975 (CHEMBL3412632) |
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| Ki | 2384±n/a nM |
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| Citation |  Hu, M; Giulianotti, MA; McLaughlin, JP; Shao, J; Debevec, G; Maida, LE; Geer, P; Cazares, M; Misler, J; Li, L; Dooley, C; Ganno, ML; Eans, SO; Mizrachi, E; Santos, RG; Yongye, AB; Houghten, RA; Yu, Y Synthesis and biological evaluations of novel endomorphin analogues containinga-hydroxy-ß-phenylalanine (AHPBA) displaying mixedµ/d opioid receptor agonist andd opioid receptor antagonist activities. Eur J Med Chem92:270-81 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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| BDBM50071092 |
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| n/a |
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| Name | BDBM50071092 |
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| Synonyms: | CHEMBL3409755 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H40N6O6 |
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| Mol. Mass. | 640.7287 |
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| SMILES | N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r| |
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| Structure | 
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