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TargetKynurenine 3-monooxygenase
LigandBDBM50072127
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1467938
IC50 22±n/a nM
Citation Toledo-Sherman LMPrime MEMrzljak LBeconi MGBeresford ABrookfield FABrown CJCardaun ICourtney SMDijkman UHamelin-Flegg EJohnson PDKempf VLyons KMatthews KMitchell WLO'Connell CPena PPowell KRassoulpour AReed LReindl WSelvaratnam SFriley WWWeddell DAWent NEWheelan PWinkler CWinkler DWityak JYarnold CJYates DMunoz-Sanjuan IDominguez C Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease. J Med Chem 58:1159-83 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine 3-monooxygenase
Name:Kynurenine 3-monooxygenase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:55831.03
Organism:Homo sapiens (Human)
Description:ChEMBL_1487479
Residue:486
Sequence:
MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
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  Blast E-value cutoff:
BDBM50072127
n/a
NameBDBM50072127
Synonyms:CHEMBL3407909
TypeSmall organic molecule
Emp. Form.C12H7F3N2O2
Mol. Mass.268.1914
SMILESOC(=O)c1cc(ncn1)-c1cccc(c1)C(F)(F)F
Structure
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