Reaction Details |
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Target | Cyclin-dependent kinase 2 |
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Ligand | BDBM50081185 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1475748 (CHEMBL3424981) |
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IC50 | 12295±n/a nM |
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Citation | Kettle, JG; Ballard, P; Bardelle, C; Cockerill, M; Colclough, N; Critchlow, SE; Debreczeni, J; Fairley, G; Fillery, S; Graham, MA; Goodwin, L; Guichard, S; Hudson, K; Ward, RA; Whittaker, D Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem58:2834-44 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2 |
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Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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BDBM50081185 |
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n/a |
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Name | BDBM50081185 |
Synonyms: | CHEMBL3421963 |
Type | Small organic molecule |
Emp. Form. | C23H25N7O |
Mol. Mass. | 415.4909 |
SMILES | COc1cc(ccc1Nc1cc(ncn1)-c1c[nH]c2cnccc12)N1CCN(C)CC1 |
Structure |
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