Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily H member 2 | ||
Ligand | BDBM50084100 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1477141 (CHEMBL3428450) | ||
IC50 | >60000±n/a nM | ||
Citation | Singh, SB; Kaelin, DE; Wu, J; Miesel, L; Tan, CM; Gill, C; Black, T; Nargund, R; Meinke, PT; Olsen, DB; Lagrutta, A; Wei, C; Peng, X; Wang, X; Fukuda, H; Kishii, R; Takei, M; Takeuchi, T; Shibue, T; Ohata, K; Takano, H; Ban, S; Nishimura, A; Fukuda, Y Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3). Bioorg Med Chem Lett25:2473-8 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily H member 2 | |||
Name: | Potassium voltage-gated channel subfamily H member 2 | ||
Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 126672.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q12809 | ||
Residue: | 1159 | ||
Sequence: |
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BDBM50084100 | |||
n/a | |||
Name | BDBM50084100 | ||
Synonyms: | CHEMBL3425813 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H26FN5O5 | ||
Mol. Mass. | 519.5242 | ||
SMILES | O[C@@]1(CC23CCC(CC2)(CO3)NCc2ncc3OCCOc3c2C#N)Cn2c3c1c(F)cnc3ccc2=O |r,wD:1.0,(2.14,2.31,;.92,2.5,;.32,3.91,;-1.21,4.13,;-1.59,2.67,;-3.12,2.49,;-4.05,3.74,;-2.63,3.19,;-2.41,4.71,;-3.43,5.14,;-1.91,5.34,;-5.55,3.5,;-6.11,2.06,;-7.63,1.82,;-8.6,3.03,;-10.14,2.78,;-10.69,1.34,;-12.22,1.11,;-12.78,-.33,;-11.81,-1.53,;-10.29,-1.3,;-9.73,.14,;-8.21,.38,;-7.24,-.83,;-6.48,-1.8,;-1,2.52,;-1.3,1,;,.24,;1.32,1,;2.63,.24,;3.7,.86,;2.63,-1.26,;1.32,-2.01,;,-1.26,;-1.3,-2.01,;-2.61,-1.26,;-2.61,.24,;-3.68,.86,)| | ||
Structure |