Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily H member 2 | ||
Ligand | BDBM50084102 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1477140 (CHEMBL3428449) | ||
IC50 | >60000±n/a nM | ||
Citation | Singh, SB; Kaelin, DE; Wu, J; Miesel, L; Tan, CM; Gill, C; Black, T; Nargund, R; Meinke, PT; Olsen, DB; Lagrutta, A; Wei, C; Peng, X; Wang, X; Fukuda, H; Kishii, R; Takei, M; Takeuchi, T; Shibue, T; Ohata, K; Takano, H; Ban, S; Nishimura, A; Fukuda, Y Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3). Bioorg Med Chem Lett25:2473-8 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily H member 2 | |||
Name: | Potassium voltage-gated channel subfamily H member 2 | ||
Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 126672.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q12809 | ||
Residue: | 1159 | ||
Sequence: |
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BDBM50084102 | |||
n/a | |||
Name | BDBM50084102 | ||
Synonyms: | CHEMBL3425814 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H26ClFN4O5 | ||
Mol. Mass. | 528.96 | ||
SMILES | O[C@@]1(CC23CCC(CC2)(CO3)NCc2ncc3OCCOc3c2Cl)Cn2c3c1c(F)cnc3ccc2=O |r,wD:1.0,(2.15,2.32,;.93,2.51,;.33,3.93,;-1.21,4.14,;-1.59,2.68,;-3.13,2.5,;-4.07,3.76,;-2.64,3.2,;-2.42,4.73,;-3.45,5.16,;-1.92,5.36,;-5.58,3.52,;-6.14,2.07,;-7.67,1.83,;-8.64,3.04,;-10.18,2.79,;-10.74,1.35,;-12.27,1.11,;-12.83,-.33,;-11.86,-1.54,;-10.33,-1.3,;-9.77,.14,;-8.24,.38,;-7.47,-.59,;-1,2.53,;-1.3,1,;,.25,;1.32,1,;2.64,.25,;3.72,.87,;2.64,-1.26,;1.32,-2.02,;,-1.26,;-1.3,-2.02,;-2.62,-1.26,;-2.62,.25,;-3.7,.87,)| | ||
Structure |