Reaction Details |
| Report a problem with these data |
Target | Ephrin type-A receptor 2 |
---|
Ligand | BDBM50086441 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1476353 (CHEMBL3429876) |
---|
IC50 | 16±n/a nM |
---|
Citation | Zhang, CH; Zheng, MW; Li, YP; Lin, XD; Huang, M; Zhong, L; Li, GB; Zhang, RJ; Lin, WT; Jiao, Y; Wu, XA; Yang, J; Xiang, R; Chen, LJ; Zhao, YL; Cheng, W; Wei, YQ; Yang, SY Design, Synthesis, and Structure-Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src Inhibitors with Potent Activities in Models of Triple Negative Breast Cancer. J Med Chem58:3957-74 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Ephrin type-A receptor 2 |
---|
Name: | Ephrin type-A receptor 2 |
Synonyms: | ECK | EPHA2 | EPHA2_HUMAN | Ephrin receptor | Epithelial cell kinase | Tyrosine-protein kinase receptor ECK |
Type: | PROTEIN |
Mol. Mass.: | 108260.70 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1505248 |
Residue: | 976 |
Sequence: | MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMN
DMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFN
LYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGG
EEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPS
PEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDI
VYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSG
LVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSN
SYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGG
VAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQA
VLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF
LGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGML
RGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIP
IRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPM
DCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSG
SEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAY
SLLGLKDQVNTVGIPI
|
|
|
BDBM50086441 |
---|
n/a |
---|
Name | BDBM50086441 |
Synonyms: | CHEMBL3426225 | US10266537, Compound 3 |
Type | Small organic molecule |
Emp. Form. | C30H31F3N8O |
Mol. Mass. | 576.6153 |
SMILES | CCn1nc(C#Cc2cc(ccc2C)C(=O)Nc2ccc(CN3CCN(C)CC3)c(c2)C(F)(F)F)c2c(N)ncnc12 |
Structure |
|