| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50094772 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1504574 (CHEMBL3591315) |
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| Ki | 23±n/a nM |
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| Citation |  Eans, SO; Ganno, ML; Mizrachi, E; Houghten, RA; Dooley, CT; McLaughlin, JP; Nefzi, A Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities atµ (MOR),d (DOR), and¿ (KOR) Opioid Receptors. J Med Chem58:4905-17 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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| BDBM50094772 |
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| n/a |
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| Name | BDBM50094772 |
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| Synonyms: | CHEMBL3589796 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H42N4O |
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| Mol. Mass. | 486.6914 |
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| SMILES | CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@H](CN=C3C=C2N1CCc1ccccc1)C(C)C |r,c:21,24| |
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| Structure | 
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