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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Potassium voltage-gated channel subfamily H member 2 | ||
| Ligand | BDBM50082303 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1510551 (CHEMBL3607786) | ||
| IC50 | 2000±n/a nM | ||
| Citation |  Singh, SB; Kaelin, DE; Wu, J; Miesel, L; Tan, CM; Meinke, PT; Olsen, DB; Lagrutta, A; Wei, C; Liao, Y; Peng, X; Wang, X; Fukuda, H; Kishii, R; Takei, M; Yajima, M; Shibue, T; Shibata, T; Ohata, K; Nishimura, A; Fukuda, Y Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6). Bioorg Med Chem Lett25:3636-43 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Potassium voltage-gated channel subfamily H member 2 | |||
| Name: | Potassium voltage-gated channel subfamily H member 2 | ||
| Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 126672.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q12809 | ||
| Residue: | 1159 | ||
| Sequence: |
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| BDBM50082303 | |||
| n/a | |||
| Name | BDBM50082303 | ||
| Synonyms: | CHEMBL3305005 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H28FN5O4 | ||
| Mol. Mass. | 493.53 | ||
| SMILES | COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1 |(5.32,-5.97,;5.32,-7.51,;6.66,-8.28,;6.65,-9.83,;7.99,-10.6,;9.32,-9.82,;10.66,-10.59,;11.99,-9.81,;11.98,-8.26,;11.97,-6.72,;10.65,-7.5,;10.64,-5.96,;11.97,-5.19,;13.3,-5.95,;13.3,-7.49,;14.63,-8.25,;15.97,-7.48,;15.28,-6.35,;14.06,-7.27,;15.96,-5.94,;14.62,-5.17,;17.29,-8.27,;17.28,-9.81,;18.6,-10.59,;19.93,-9.84,;21.25,-10.62,;21.24,-12.16,;22.57,-12.94,;22.54,-14.49,;21.2,-15.24,;21.18,-16.78,;19.88,-14.45,;19.9,-12.92,;18.57,-12.13,;9.32,-8.28,;7.98,-7.51,)| | ||
| Structure | 
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