Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetBeta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
LigandBDBM50117662
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1515027
IC50 6.0±n/a nM
Citation Huard KLondregan ATTesz GBahnck KBMagee TVHepworth DPolivkova JCoffey SBPabst BAGosset JRNigam AKou KSun HLee KHerr MBoehm MCarpino PAGoodwin BPerreault CLi QJorgensen CCTkalcevic GTSubashi TAAhn K Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3. J Med Chem 58:7164-72 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Name:Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Synonyms:GGNT3 | GNT-III | GlcNAc-T III | MGAT3 | N-acetylglucosaminyltransferase III | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
Type:PROTEIN
Mol. Mass.:61324.81
Organism:Homo sapiens (Human)
Description:ChEMBL_107586
Residue:533
Sequence:
MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQA
SPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKP
GTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGP
SCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCES
NFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDG
VSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLE
VVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCS
WCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEH
MYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50117662
n/a
NameBDBM50117662
Synonyms:CHEMBL3613706
TypeSmall organic molecule
Emp. Form.C25H23N5O4S
Mol. Mass.489.546
SMILESCOc1cccc(CC(=O)N2Cc3ccc(cc3C2)S(=O)(=O)Nc2cnn(n2)-c2ccccc2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: