Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50130509 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1525487 (CHEMBL3636685) |
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IC50 | 447±n/a nM |
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Citation | Elkamhawy, A; Viswanath, AN; Pae, AN; Kim, HY; Heo, JC; Park, WK; Lee, CO; Yang, H; Kim, KH; Nam, DH; Seol, HJ; Cho, H; Roh, EJ Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). Eur J Med Chem103:210-22 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50130509 |
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n/a |
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Name | BDBM50130509 |
Synonyms: | CHEMBL3634097 |
Type | Small organic molecule |
Emp. Form. | C22H15Cl3N4O2 |
Mol. Mass. | 473.739 |
SMILES | Clc1ccc(NC(=O)Nc2cc3ncncc3cc2OCc2ccccc2Cl)cc1Cl |
Structure |
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