| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholinesterase |
|---|
| Ligand | BDBM50131717 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1525849 (CHEMBL3635763) |
|---|
| IC50 | 3120±n/a nM |
|---|
| Citation |  Mostofi, M; Mohammadi Ziarani, G; Mahdavi, M; Moradi, A; Nadri, H; Emami, S; Alinezhad, H; Foroumadi, A; Shafiee, A Synthesis and structure-activity relationship study of benzofuran-based chalconoids bearing benzylpyridinium moiety as potent acetylcholinesterase inhibitors. Eur J Med Chem103:361-9 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acetylcholinesterase |
|---|
| Name: | Acetylcholinesterase |
|---|
| Synonyms: | 3.1.1.7 | ACES_TETCF | Acetylcholinesterase (AChE) | Acetylcholinesterase precursor | ache |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 65900.74 |
|---|
| Organism: | Tetronarce californica (Pacific electric ray) (Torpedo californica) |
|---|
| Description: | P04058 |
|---|
| Residue: | 586 |
|---|
| Sequence: | MNLLVTSSLGVLLHLVVLCQADDHSELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPP
VGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNI
WVPSPRPKSTTVMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALH
GSQEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLF
RRAILQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEW
NVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPGF
SKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHN
VICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNYT
AEEEALSRRIMHYWATFAKTGNPNEPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQ
MCVFWNQFLPKLLNATACDGELSSSGTSSSKGIIFYVLFSILYLIF
|
|
|
|---|
| BDBM50131717 |
|---|
| n/a |
|---|
| Name | BDBM50131717 |
|---|
| Synonyms: | CHEMBL3633871 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H16Cl3NO2 |
|---|
| Mol. Mass. | 444.738 |
|---|
| SMILES | [Cl-].Clc1cccc(C[n+]2ccc(\C=C\C(=O)c3cc4ccccc4o3)cc2)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
