| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Tec |
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| Ligand | BDBM50134320 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1544629 (CHEMBL3750473) |
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| IC50 | 230±n/a nM |
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| Citation |  Young, WB; Barbosa, J; Blomgren, P; Bremer, MC; Crawford, JJ; Dambach, D; Eigenbrot, C; Gallion, S; Johnson, AR; Kropf, JE; Lee, SH; Liu, L; Lubach, JW; Macaluso, J; Maciejewski, P; Mitchell, SA; Ortwine, DF; Di Paolo, J; Reif, K; Scheerens, H; Schmitt, A; Wang, X; Wong, H; Xiong, JM; Xu, J; Yu, C; Zhao, Z; Currie, KS Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability. Bioorg Med Chem Lett26:575-9 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Tec |
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| Name: | Tyrosine-protein kinase Tec |
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| Synonyms: | PSCTK4 | TEC | TEC_HUMAN | Tyrosine-protein kinase TEC (TEC) |
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| Type: | Protein |
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| Mol. Mass.: | 73597.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 631 |
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| Sequence: | MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK
CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY
HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS
EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN
NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY
HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY
EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL
THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL
ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS
RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR
CWQEKPEGRPSFEDLLRTIDELVECEETFGR
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| BDBM50134320 |
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| n/a |
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| Name | BDBM50134320 |
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| Synonyms: | CHEMBL3746293 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24FN7O2S |
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| Mol. Mass. | 529.589 |
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| SMILES | CN1CCn2nc(Nc3cc(n[nH]c3=O)-c3ccc(F)c(NC(=O)c4cc5ccccc5s4)c3C)cc2C1 |
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| Structure | 
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