Reaction Details |
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Target | Beta-3 adrenergic receptor |
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Ligand | BDBM50146156 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1554626 (CHEMBL3768722) |
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EC50 | 3.5±n/a nM |
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Citation | Edmondson, SD; Zhu, C; Kar, NF; Di Salvo, J; Nagabukuro, H; Sacre-Salem, B; Dingley, K; Berger, R; Goble, SD; Morriello, G; Harper, B; Moyes, CR; Shen, DM; Wang, L; Ball, R; Fitzmaurice, A; Frenkl, T; Gichuru, LN; Ha, S; Hurley, AL; Jochnowitz, N; Levorse, D; Mistry, S; Miller, RR; Ormes, J; Salituro, GM; Sanfiz, A; Stevenson, AS; Villa, K; Zamlynny, B; Green, S; Struthers, M; Weber, AE Discovery of Vibegron: A Potent and Selectiveß3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder. J Med Chem59:609-23 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-3 adrenergic receptor |
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Name: | Beta-3 adrenergic receptor |
Synonyms: | ADRB3 | ADRB3_MACMU | B3AR | Beta-3 adrenoceptor | Beta-3 adrenoreceptor |
Type: | PROTEIN |
Mol. Mass.: | 44674.60 |
Organism: | Macaca mulatta |
Description: | ChEMBL_108044 |
Residue: | 418 |
Sequence: | MAPWPHGNSSLVPWPDVPTLAPNTANTSGLPGVPWAAALAGALLALAVLATVGGNLLVIV
AITRTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLVLTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRW
ELGRFPPEESSPALSRSLAPAPAGTCAPPEGVPACCRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPDPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CHCGGRLPREPCAADRPASSPRAPLRPGPAPRSPGFASGSTGLLGEFLRPEGQEATLR
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BDBM50146156 |
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n/a |
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Name | BDBM50146156 |
Synonyms: | CHEMBL3764088 |
Type | Small organic molecule |
Emp. Form. | C24H26N4O3 |
Mol. Mass. | 418.4882 |
SMILES | [H][C@@]1(CC[C@@H](Cc2ccc(NC(=O)Cn3ncccc3=O)cc2)N1)[C@H](O)c1ccccc1 |r| |
Structure |
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