| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tissue-type plasminogen activator |
|---|
| Ligand | BDBM50153004 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1564078 |
|---|
| Ki | 10500±n/a nM |
|---|
| Citation |  Corte JR; Fang T; Pinto DJ; Orwat MJ; Rendina AR; Luettgen JM; Rossi KA; Wei A; Ramamurthy V; Myers JE; Sheriff S; Narayanan R; Harper TW; Zheng JJ; Li YX; Seiffert DA; Wexler RR; Quan ML Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group. Bioorg Med Chem 24:2257-72 (2016) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tissue-type plasminogen activator |
|---|
| Name: | Tissue-type plasminogen activator |
|---|
| Synonyms: | Alteplase | Reteplase | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 62931.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 562 |
|---|
| Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
|
|
|
|---|
| BDBM50153004 |
|---|
| n/a |
|---|
| Name | BDBM50153004 |
|---|
| Synonyms: | CHEMBL3781319 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H26ClN7O3 |
|---|
| Mol. Mass. | 580.036 |
|---|
| SMILES | COC(=O)Nc1ccc(cc1)-c1ccnc(c1)[C@H](Cc1ccccc1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
