Reaction Details | |||
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Target | Insulin receptor | ||
Ligand | BDBM50157879 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1570092 (CHEMBL3789694) | ||
IC50 | 1018±n/a nM | ||
Citation | Fairhurst, RA; Marsilje, TH; Stutz, S; Boos, A; Niklaus, M; Chen, B; Jiang, S; Lu, W; Furet, P; McCarthy, C; Stauffer, F; Guagnano, V; Vaupel, A; Michellys, PY; Schnell, C; Jeay, S Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors. Bioorg Med Chem Lett26:2057-64 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Insulin receptor | |||
Name: | Insulin receptor | ||
Synonyms: | INSR | INSR protein | INSR_HUMAN | Insulin receptor (IR) | Insulin receptor beta subunit | ||
Type: | Receptor Tyrosine Kinase | ||
Mol. Mass.: | 156322.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P06213 | ||
Residue: | 1382 | ||
Sequence: |
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BDBM50157879 | |||
n/a | |||
Name | BDBM50157879 | ||
Synonyms: | CHEMBL1614712 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H29N5O | ||
Mol. Mass. | 439.5521 | ||
SMILES | [H][C@]1(CN2CCC2)C[C@]([H])(C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12 |wD:8.9,1.0,(6.47,-15.11,;5.71,-13.78,;4.93,-15.11,;5.69,-16.44,;5.68,-17.98,;7.22,-17.99,;7.23,-16.45,;5.31,-12.3,;6.81,-11.9,;6.02,-10.55,;7.2,-13.39,;7.59,-10.56,;6.61,-9.37,;7.45,-8.07,;7.04,-6.58,;5.56,-6.19,;5.15,-4.71,;6.24,-3.6,;7.73,-3.99,;8.81,-2.89,;10.15,-3.66,;11.48,-2.89,;12.81,-3.66,;14.12,-2.9,;14.13,-1.36,;12.8,-.59,;11.48,-1.36,;8.13,-5.47,;8.94,-8.47,;10.35,-7.7,;10.34,-6.15,;11.69,-8.46,;11.69,-10.01,;10.35,-10.79,;9.02,-10.01,)| | ||
Structure |