| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-sensitive inward rectifier potassium channel 1 |
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| Ligand | BDBM50163359 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1571175 (CHEMBL3797006) |
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| IC50 | 95±n/a nM |
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| Citation |  Walsh, SP; Shahripour, A; Tang, H; de Jesus, RK; Teumelsan, N; Zhu, Y; Frie, J; Priest, BT; Swensen, AM; Alonso-Galicia, M; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Zhou, X; Pai, LY; Hampton, C; Hernandez, M; Owens, K; Ehrhart, J; Roy, S; Kaczorowski, GJ; Yang, L; Garcia, ML; Pasternak, A Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation. Bioorg Med Chem Lett26:2339-43 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-sensitive inward rectifier potassium channel 1 |
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| Name: | ATP-sensitive inward rectifier potassium channel 1 |
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| Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44809.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_223460826 |
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| Residue: | 391 |
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| Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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| BDBM50163359 |
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| n/a |
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| Name | BDBM50163359 |
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| Synonyms: | CHEMBL3794292 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27N7O3 |
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| Mol. Mass. | 461.5163 |
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| SMILES | CC(CN1CCN(CC1)C(=O)Cc1ccc(nc1)-n1cnnn1)c1ccc2C(=O)OCc2c1C |
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| Structure | 
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