| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier organic anion transporter family member 1B1 |
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| Ligand | BDBM50180850 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1584903 (CHEMBL3819823) |
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| IC50 | 2500±n/a nM |
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| Citation |  Davies, TG; Wixted, WE; Coyle, JE; Griffiths-Jones, C; Hearn, K; McMenamin, R; Norton, D; Rich, SJ; Richardson, C; Saxty, G; Willems, HM; Woolford, AJ; Cottom, JE; Kou, JP; Yonchuk, JG; Feldser, HG; Sanchez, Y; Foley, JP; Bolognese, BJ; Logan, G; Podolin, PL; Yan, H; Callahan, JF; Heightman, TD; Kerns, JK Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J Med Chem59:3991-4006 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier organic anion transporter family member 1B1 |
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| Name: | Solute carrier organic anion transporter family member 1B1 |
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| Synonyms: | LST1 | OATP1B1 | OATP2 | OATPC | SLC21A6 | SLCO1B1 | SO1B1_HUMAN | Solute carrier organic anion transporter family member 1B1 | Solute carrier organic anion transporter family member 1B1 (OATP1B1) | Thromboxane B2 |
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| Type: | Protein |
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| Mol. Mass.: | 76468.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y6L6 |
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| Residue: | 691 |
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| Sequence: | MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFE
ISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGY
YRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNML
RGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYV
DLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLE
TNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVF
KYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLS
FYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGIT
YISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAI
QVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCI
KWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASE
NGSVMDEANLESLNKNKHFVPSAGADSETHC
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| BDBM50180850 |
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| n/a |
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| Name | BDBM50180850 |
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| Synonyms: | CHEMBL3819587 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30N4O6S |
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| Mol. Mass. | 550.626 |
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| SMILES | COc1cc(cc2nnn(C)c12)[C@@H](CC(O)=O)c1ccc(C)c(CN2C[C@@H](C)Oc3ccccc3S2(=O)=O)c1 |r| |
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| Structure | 
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