Reaction Details |
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Target | Signal transducer and activator of transcription 3 |
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Ligand | BDBM50189972 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1591092 (CHEMBL3829060) |
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IC50 | 3400±n/a nM |
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Citation | LaPorte, MG; Wang, Z; Colombo, R; Garzan, A; Peshkov, VA; Liang, M; Johnston, PA; Schurdak, ME; Sen, M; Camarco, DP; Hua, Y; Pollock, NI; Lazo, JS; Grandis, JR; Wipf, P; Huryn, DM Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. Bioorg Med Chem Lett26:3581-5 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Signal transducer and activator of transcription 3 |
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Name: | Signal transducer and activator of transcription 3 |
Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) |
Type: | Protein |
Mol. Mass.: | 88064.31 |
Organism: | Homo sapiens (Human) |
Description: | P40763 |
Residue: | 770 |
Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
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BDBM50189972 |
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n/a |
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Name | BDBM50189972 |
Synonyms: | CHEMBL3828048 | US10618914, Compound 21 | US11111253, Compound 21 |
Type | Small organic molecule |
Emp. Form. | C20H16N6S |
Mol. Mass. | 372.446 |
SMILES | CC1Sc2nnc(-c3cc(n[nH]3)-c3ccccc3)n2N=C1c1ccccc1 |c:22| |
Structure |
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