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TargetCoagulation factor III/Factor VIIa (fVIIa)
LigandBDBM50192771
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1613695
Ki 0.550000±n/a nM
Citation Ladziata VUGlunz PWZou YZhang XJiang WJacutin-Porte SCheney DLWei ALuettgen JMHarper TMWong PCSeiffert DWexler RRPriestley ES Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors. Bioorg Med Chem Lett 26:5051-5057 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor III/Factor VIIa (fVIIa)
Name:Coagulation factor III/Factor VIIa (fVIIa)
Synonyms:Coagulation factor III/VII | Coagulation factor VII/tissue factor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 69535
Components:This complex has 2 components.
Component 1
Name:Coagulation factor VII/tissue factor
Synonyms:CD_antigen=CD142 | Coagulation factor III | TF | Thromboplastin | Tissue factor
Type:PROTEIN
Mol. Mass.:33067.61
Organism:Homo sapiens (Human)
Description:ChEMBL_936735
Residue:295
Sequence:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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Component 2
Name:Thrombin and coagulation factor VII
Synonyms:Eptacog alfa | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | serum prothrombin conversion accelerator
Type:Enzyme
Mol. Mass.:51599.89
Organism:Homo sapiens (Human)
Description:n/a
Residue:466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM50192771
n/a
NameBDBM50192771
Synonyms:CHEMBL3898371
TypeSmall organic molecule
Emp. Form.C34H34FN5O5
Mol. Mass.611.6627
SMILES[H][C@]1(C)COC(=O)Nc2ccc(c(CN(C)C(=O)[C@]([H])(Nc3ccc4c(c3)c(F)c[nH]c4=N)c3ccc1c(C)c3)c2)C1(CC1)C(O)=O |r|
Structure
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