| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid hormone receptor ERR1 |
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| Ligand | BDBM22435 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1615019 (CHEMBL3857088) |
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| IC50 | >10000±n/a nM |
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| Citation |  Kim, J; Chin, J; Im, CY; Yoo, EK; Woo, S; Hwang, HJ; Cho, JH; Seo, KA; Song, J; Hwang, H; Kim, KH; Kim, ND; Yoon, SK; Jeon, JH; Yoon, SY; Jeon, YH; Choi, HS; Lee, IK; Kim, SH; Cho, SJ Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists. Eur J Med Chem120:338-52 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid hormone receptor ERR1 |
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| Name: | Steroid hormone receptor ERR1 |
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| Synonyms: | ERR-alpha | ERR1 | ERR1_HUMAN | ESRL1 | ESRRA | Estrogen receptor-like 1 | Estrogen-Related Receptor, alpha | Estrogen-related receptor alpha | NR3B1 | Nuclear receptor subfamily 3 group B member 1 | Steroid hormone receptor ERR1 | Steroid hormone receptor ERR1 alpha | Steroid hormone receptor ERR1/Estrogen-related receptor alpha (ERRa) | von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45508.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1499891 |
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| Residue: | 423 |
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| Sequence: | MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAG
PGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNE
CEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGP
LAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTI
SWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAA
GLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALL
EYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEA
MMD
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|
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| BDBM22435 |
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| n/a |
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| Name | BDBM22435 |
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| Synonyms: | 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hydroxy-2-phenylpent-1-en-1-yl]phenol | 4-hydroxytamoxifen (4-OHT) analog, 15 | GSK 5182 | US10934303, Example GSK5182 | US11285226, Compound GSK5182 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31NO3 |
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| Mol. Mass. | 417.5399 |
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| SMILES | CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1 |
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| Structure | 
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