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TargetCytochrome P450 2D6
LigandBDBM50204032
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1625989 (CHEMBL3868458)
IC50>20000±n/a nM
Citation Wu, WLBurnett, DAClader, JGreenlee, WJJiang, QHyde, LADel Vecchio, RACohen-Williams, MESong, LLee, JTerracina, GZhang, QNomeir, AParker, EMZhang, L Design and synthesis of water solubleß-aminosulfone analogues of SCH 900229 as¿-secretase inhibitors. Bioorg Med Chem Lett26:5836-5841 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50204032
n/a
NameBDBM50204032
Synonyms:CHEMBL3903590
TypeSmall organic molecule
Emp. Form.C26H31ClF2N2O6S2
Mol. Mass.605.114
SMILES[H][C@@]12COc3c(F)ccc(F)c3[C@@]1(CCO[C@H]2CCS(=O)(=O)CCN1CCNCC1)S(=O)(=O)c1ccc(Cl)cc1 |r|
Structure
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