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TargetAcetylcholine receptor subunit delta
LigandBDBM50211195
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1636037
EC50>100000±n/a nM
Citation Cook JZusi FCMcDonald IMKing DHill MDIwuagwu CMate RAFang HZhao RWang BCutrone JMa BGao QKnox RJMatchett MGallagher LFerrante MPost-Munson DMolski TEaston AMiller RJones KDigavalli SHealy FLentz KBenitex YClarke WNatale JSiuciak JALodge NZaczek RDenton RMorgan DBristow LJMacor JEOlson RE Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship. J Med Chem 59:11171-11181 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acetylcholine receptor subunit delta
Name:Acetylcholine receptor subunit delta
Synonyms:Acetylcholine receptor subunit delta | Acrd | Chrnd
Type:PROTEIN
Mol. Mass.:58877.21
Organism:Rattus norvegicus
Description:ChEMBL_117053
Residue:517
Sequence:
MAGPVPTLGLLAALVVCGSWGLNEEQRLIQHLFEEKGYNKELRPVARKEDIVDVALSLTL
SNLISLKEVEETLTTNVWIDHAWIDSRLQWNANEFGNITVLRLPSDMVWLPEIVLENNND
GSFQISYACNVLVSDSGHVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIR
LSLKQEEEDNRSYPIEWIIIDPEGFTENGEWEIVHRAAKVNVDPSVPMDSTNHQDVTFYL
IIRRKPLFYIINILVPCVLISFMINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLP
ATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKFFLETLPKLLH
MSRPEEEDPGPRALIRRTSSLGYISKAEEYFSLKSRSDLMFEKQSERHGLARRLTTARKP
PASSEQVQQELFNEMKPAVDGANFIVNHMRDQNSYNEEKDNWNQVARTVDRLCLFVVTPV
MVVGTAWIFLQGVYNQPPPQPFPGDPFSYDEQDRRFI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50211195
n/a
NameBDBM50211195
Synonyms:CHEMBL3944506
TypeSmall organic molecule
Emp. Form.C17H20N4O2S
Mol. Mass.344.431
SMILESCOc1ccc2nc(NC3=NC[C@@]4(CN5CCC4CC5)O3)sc2c1 |r,wU:12.21,t:9,THB:20:12:15.16:19.18,(37.09,-40.85,;35.6,-40.46,;34.52,-41.55,;34.92,-43.04,;33.83,-44.12,;32.35,-43.73,;31.07,-44.57,;29.87,-43.61,;28.38,-44.01,;27.98,-45.5,;28.96,-46.69,;28.12,-47.99,;26.63,-47.59,;26.93,-49.11,;25.44,-48.42,;23.78,-49.14,;23.56,-47.64,;25.16,-46.94,;25.24,-45.16,;25.72,-46.36,;26.55,-46.05,;30.42,-42.17,;31.96,-42.24,;33.04,-41.16,)|
Structure
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