Reaction Details |
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Target | Farnesyl pyrophosphate synthase |
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Ligand | BDBM50235466 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1657315 (CHEMBL4006785) |
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IC50 | 10000±n/a nM |
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Citation | Park, J; Leung, CY; Matralis, AN; Lacbay, CM; Tsakos, M; Fernandez De Troconiz, G; Berghuis, AM; Tsantrizos, YS Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J Med Chem60:2119-2134 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Farnesyl pyrophosphate synthase |
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Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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BDBM50235466 |
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n/a |
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Name | BDBM50235466 |
Synonyms: | CHEMBL4097575 |
Type | Small organic molecule |
Emp. Form. | C15H16N3O3PS |
Mol. Mass. | 349.345 |
SMILES | Cc1c(sc2ncnc(NCP(O)(O)=O)c12)-c1ccc(C)cc1 |
Structure |
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