Reaction Details |
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Target | Polycomb protein EED |
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Ligand | BDBM172038 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1658555 (CHEMBL4008167) |
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IC50 | 40±n/a nM |
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Citation | Huang, Y; Zhang, J; Yu, Z; Zhang, H; Wang, Y; Lingel, A; Qi, W; Gu, J; Zhao, K; Shultz, MD; Wang, L; Fu, X; Sun, Y; Zhang, Q; Jiang, X; Zhang, J; Zhang, C; Li, L; Zeng, J; Feng, L; Zhang, C; Liu, Y; Zhang, M; Zhang, L; Zhao, M; Gao, Z; Liu, X; Fang, D; Guo, H; Mi, Y; Gabriel, T; Dillon, MP; Atadja, P; Oyang, C Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. J Med Chem60:2215-2226 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polycomb protein EED |
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Name: | Polycomb protein EED |
Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
Type: | Protein |
Mol. Mass.: | 50201.68 |
Organism: | Homo sapiens (Human) |
Description: | O75530 |
Residue: | 441 |
Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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BDBM172038 |
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n/a |
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Name | BDBM172038 |
Synonyms: | US10155002, Compound 44 | US10647700, Compound EPZ6438 | US11052093, Compound 143 | US11535629, Compound Control A | US9090562, 143 | US9090562, 44 | US9394283, 1 |
Type | Small organic molecule |
Emp. Form. | C34H44N4O4 |
Mol. Mass. | 572.7376 |
SMILES | CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1 |
Structure |
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