| Reaction Details |
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 | Report a problem with these data |
| Target | m7GpppX diphosphatase |
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| Ligand | BDBM50237212 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1660723 (CHEMBL4010335) |
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| IC50 | 12±n/a nM |
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| Citation |  Gopalsamy, A; Narayanan, A; Liu, S; Parikh, MD; Kyne, RE; Fadeyi, O; Tones, MA; Cherry, JJ; Nabhan, JF; LaRosa, G; Petersen, DN; Menard, C; Foley, TL; Noell, S; Ren, Y; Loria, PM; Maglich-Goodwin, J; Rong, H; Jones, LH Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem60:3094-3108 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| m7GpppX diphosphatase |
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| Name: | m7GpppX diphosphatase |
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| Synonyms: | DCPS | DCPS_HUMAN | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS) |
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| Type: | Enzyme |
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| Mol. Mass.: | 38606.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96C86 |
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| Residue: | 337 |
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| Sequence: | MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDK
IIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFP
PRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNIL
DKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPL
LRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAE
VIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
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| BDBM50237212 |
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| n/a |
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| Name | BDBM50237212 |
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| Synonyms: | CHEMBL4100442 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26FN5O |
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| Mol. Mass. | 395.4731 |
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| SMILES | Cc1cc(OCC2CCN(Cc3ccccc3F)CC2)c2c(N)nc(N)nc2c1 |
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| Structure | 
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