| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor 2 |
|---|
| Ligand | BDBM86750 |
|---|
| Substrate/Competitor | n/a |
|---|
| Ki | 820±n/a nM |
|---|
| Comments | PDSP_6665 |
|---|
| Citation |  Weiss, B; Alt, A; Ogden, AM; Gates, M; Dieckman, DK; Clemens-Smith, A; Ho, KH; Jarvie, K; Rizkalla, G; Wright, RA; Calligaro, DO; Schoepp, D; Mattiuz, EL; Stratford, RE; Johnson, B; Salhoff, C; Katofiasc, M; Phebus, LA; Schenck, K; Cohen, M; Filla, SA; Ornstein, PL; Johnson, KW; Bleakman, D Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo. J Pharmacol Exp Ther318:772-81 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Glutamate receptor 2 |
|---|
| Name: | Glutamate receptor 2 |
|---|
| Synonyms: | AMPA-selective glutamate receptor 2 | GLUR2 | GRIA2 | GRIA2_HUMAN | GluR-2 | GluR-B | GluR-K2 | Glutamate AMPA 2 | Glutamate receptor 2 | Glutamate receptor AMPA 1/2 | Glutamate receptor AMPA 2/3 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 98825.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Glutamate AMPA 2 GRIA2 HUMAN::P42262 |
|---|
| Residue: | 883 |
|---|
| Sequence: | MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTP
HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG
THPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINV
GNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL
GFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALT
YDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNI
KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTT
ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI
WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD
PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF
SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL
SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK
YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLL
DKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR
AEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
|
|
|
|---|
| BDBM86750 |
|---|
| n/a |
|---|
| Name | BDBM86750 |
|---|
| Synonyms: | LY 302679 | LY-302679 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H20N4O4S |
|---|
| Mol. Mass. | 328.387 |
|---|
| SMILES | n/a |
|---|
| Structure | 
|
|---|
Search and Browse
